11 de setembro de 2015
Influência adversa do número de abortamentos anteriores no resultado do concentrado de leucócitos paternos em pacientes com história de Aborto Espontâneo Recorrente
Adverse Influence of Numbers of Previous
Miscarriages on Results of Paternal Lymphocyte
Immunization in Patients with Recurrent
KINUE KATANO, KOJI AOKI, MAYUMI SUGIURA OGASAWARA, AND KAORU SUZUMORI
Katano K, Aoki K, Sugiura Ogasawara M, Suzumori K. Ad6erse influence of numbers of pre6ious miscarriages on results of paternal lymphocyte immunization in patients with recurrent spontaneous abortions. AJRI 2000; 44:289–292
Problema: Determinar quando o aumento do número de abortos é um fator de risco para gravidezes subsequentes após tratamento imunológico com concentrado de leucócitos
METHOD OF STUDY: Live birth rates with reference to previous abortion numbers in recurrent spontaneous abortion patients were statistically compared between paternal lymphocyte immunotherapy and control groups, the latter retrospectively researched using historical data before 1981 in our clinic.
RESULTS: The overall live birth rate was 73% (169:232) in the immunotherapy group, and 48% (47:97) in controls (PB0.05). According to previous abortion numbers, the rates were 77% (114:148) versus 55% (36:65) (PB0.05) for three previous abortions, 70% (40:57) versus 38% (8:21) (PB0.05) for four and 56% (15:27) versus 27% (3:11) (not significant) for five, in the study and control groups, respectively.
CONCLUSIONS: The results confirm the efficacy of paternal lymphocyte immunotherapy, but demonstrate that the success rate deteriorates with the number of previous miscarriages.
Department of Obstetrics and Gynecology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Japan
Department of Obstetrics and Gynecology, Nagoya City Josai Hospital, Japan Address reprint requests to Kinue Katano, M.D., Department of Obstetrics and Gynecology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8602, Japan.